Antipyretic Therapy's future.

Brief history of antipyretic therapy.

Both external cooling and pharmacotherapy have been used to treat fever since time immemorial. In the past century such treatments have proliferated at an astonishing rate. The COX-2 inhibitors are the most recent additions to the antipyretic pharmacopoeia. Additional research is needed to determine whether they represent an important new chapter in antipyretic therapy's long history or, for th...

From mice to men: gene therapy's future for treatment of myocardial infarction.

Antipyretic Therapy in Critically Ill Patients with Sepsis: An Interaction with Body Temperature

BACKGROUND AND OBJECTIVE The effect of antipyretic therapy on mortality in patients with sepsis remains undetermined. The present study aimed to investigate the role of antipyretic therapy in ICU patients with sepsis by using a large clinical database. METHODS The multiparameter intelligent monitoring in intensive care II (MIMIC- II) database was employed for the study. Adult patients with se...

Comparative effectiveness of tepid sponging and antipyretic drug versus only antipyretic drug in the management of fever among children: a randomized controlled trial.

OBJECTIVE To compare the effectiveness of tepid sponging and antipyretic drug versus only antipyretic drug among febrile children. DESIGN Randomized controlled trial. SETTING Tertiary care hospital. PARTICIPANTS 150 children 6 mo - 12 yr age with axillary temperature 101F. INTERVENTION Tepid sponging and antipyretic drug (Paracetamol) (n=73) or only antipyretic drug (Paracetamol) (n=77)...

The Effect of Prophylactic Antipyretic Administration on Post-Vaccination Adverse Reactions and Antibody Response in Children: A Systematic Review

BACKGROUND Prophylactic antipyretic administration decreases the post-vaccination adverse reactions. Recent study finds that they may also decrease the antibody responses to several vaccine antigens. This systematic review aimed to assess the evidence for a relationship between prophylactic antipyretic administration, post-vaccination adverse events, and antibody response in children. METHODS...